Role of the X Chromosome in Social Behavioural Dysfunction and Autism-like Behaviour Created by jim@commulinks.com on 2/16/2012 3:43:22 PM
Abstract
Social cognitive competence appears to be a good predictor of social behaviour and adaptation. Individual variance in social cognitive
competence is, for a substantial part, attributable to genetic factors. Deficits in social behaviour are seen in populations such as those with
autism-spectrum disorders, and although social (dys)functioning may be similar at the level of behavioural phenotypes, it may substantially
differ with regard to the underlying cognitive and genetic pathways. In this review study it is argued that there is a need to study the
neurocognitive and behavioural phenotypes in more homogeneous genetic groups. This enables us to identify aetiological pathways to
psychopathology. In both Turner syndrome (45, XO) and Klinefelter syndrome (47, XXY), basic social-cue-processing deficits are observed,
which may contribute to difficulties in social intuition and hence in coping with social situations. The study of these two syndromes opens up
opportunities to study the influence of the X chromosome on brain behaviour developmental trajectories of social functioning and
psychopathology in heterogeneous populations.
The authors have presented at KS&A Families' Conferences and participated in KS&A Scientific Conferences.
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