This is an in-depth scientific discussion on how neurobiology may impact the ability to read and respond to social cues. It is not specific to XXY but provides a look at ongoing research.

Summary
"Social interactions with other people are distinctively coloured by emotions, in ways that are both obvious and subtle. Neuroscientists are making rapid progress in understanding the interface between the neural processing of emotions, feelings and social cognition....We still do not have a clear account of how specific allelic variation, in candidate genes, increases susceptibility to developmental disorders, such as autism, or psychiatric conditions, such as anxiety or depressive illness. However, the regulation of emotional responsiveness to social cues lies at the heart of the problem, and recent research indicates that we may be nearing a deeper and more comprehensive understanding."

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