Monday, July 28, 2014




Guide on X and Y Chromosome Variations

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In the 1980s at age 37, Virginia Isaacs Cover became pregnant with her second son. Amniocentesis revealed a prenatal diagnosis of Klinefelter Syndrome. Cover and her husband had the best genetic counseling available at the time as well as access to copies of available research studies from the Stony Brook University’s medical library. She made it her goal to develop a comprehensive guide to sex chromosome aneuploidy to ease the challenges of gaining accurate information about these genetic conditions. The author has distilled two decades of experience and study into an authoritative guide for families and individuals affected by X and Y chromosome variations.

Ms. Cover draws on her years of experience as a parent, as an advocate, and as a social worker involved with children and adults with developmental disabilities, to research psychosocial and medical issues affecting this population.  This guide provides a lifespan approach to the three trisomy conditions, Klinefelter Syndrome, Trisomy X, and 47,XYY Syndrome, as well as their less common Tetrasomy and Pentasomy variations. Living with Klinefelter Syndrome (47,XXY) Trisomy X (47,XXX) and 47,XYY provides clear explanations of the genetics involved in the conditions, diagnosis and disclosure, development from infancy through early adulthood, potential health and fertility issues, and educational and psychosocial considerations.

The Table of Contents of the 200 page guide includes:

  • An overview of the genetics and symptoms of sex chromosome aneuploidy
  • Descriptions of the trisomy aneuploid conditions and their variations
  • Klinefelter Syndrome (47,XXY) and Variations  (48,XXYY; 48,XXXY; 49,XXXXY)
  • 47,XYY
  • Trisomy X (47,XXX) and Tetrasomy and Pentasomy X (48,XXXX and 49,XXXXX)
  • Educational Recommendations
  • Psychosocial Considerations
  • Transitioning from School to Adulthood
  • What’s Next?

The guide is useful for individuals affected by extra X and Y chromosomes, as well as for teachers, counselors, social workers and health care and social services professionals working with this population.  It is written in lay language but bases its contents and recommendations on published literature as well as a survey of over 800 individuals and parents done by the author in researching this book.

Although KS&A has helped with publicizing the survey used in research for the guide and is listing it in the store on, it is not a publication of the organization.  A donation to KS&A will be made by the author for each book sold through the website.

The book is available for $16 plus $4 shipping and handling for mail to the continental U.S. by ordering here. 
We regret that due to rapidly increasing shipping rates, international shipment is no longer possible. 
International purchasers are urged to purchase the E-book, now available through Amazon.Com.


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USD $16.00

Living with Klinefelter Syndrome, Trisomy X and 47,XYY

Ship to Country Shipping Type Book Price Handling Shipping Total
Continental US Standard Media (6-10 days) $16.00 $4.00 $0 $20.00
United States (inc. AK and HI) Priority (3-5 days) $16.00 $4.00 $5.30 $25.30
*As these are not real-time shipping costs, the fees are subject to change.

We regret that, due to increases in international shipping rates, we are no longer able to ship outside the USA. 
International buyers, please choose the E-Book available through Amazon.Com.
Important Information for Express Shipment and International Orders

Basic ground shipping is included in the $4.00 shipping and handling fee.
Express shipment is available for the additional costs of packaging, labeling and shipping charges.  Contact Ginnie directly at to arrange express shipment and find out prices.  Due to the additional work needed to prepare an express shipment, the base $4.00 S&H fee still applies.

We regret that, due to increases in international shipping rates, we are no longer able to ship outside the USA. 
International buyers, please choose the E-Book available through Amazon.Com.

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